The balance of Polo-like kinase 1 in tumorigenesis
نویسندگان
چکیده
منابع مشابه
Targeting Polo - like Kinase 1 for the Treatment of Cancer
Plk1 levels start to rise significantly at the beginning of S phase, and peak after the G2/M transition [3]. Plk1 plays a critical role in centrosome maturation, kinetochore assembly, and bipolar spindle formation[4]. More importantly, Plk1 plays a key role in ensuring normal mitotic progression. It initiates mitotic entry and mitotic exit by phosphorylating Cyclin B, Cdc25c and by activating t...
متن کاملPolo-like kinase-1 in DNA damage response
Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, we discuss the role of Plk1 during DNA damage response beyond the functions in mitotsis. When DNA ...
متن کاملThe mitotic roles of Polo-like kinase.
The Polo-like protein kinases (Plks) are a conserved family of enzymes that play a variety of roles in the passage of cells through M phase (for reviews see Glover et al., 1998; Nigg, 1998). Named after the Drosophila polo gene originally identified through a recessive maternal effect lethal mutation, conserved Plk homologues have been identified in yeast, Xenopus, C. elegans and mammals. The i...
متن کاملPutting a bit into the polo-box domain of polo-like kinase 1
Polo-like kinase 1 (Plk1) plays key roles in regulating various mitotic processes that are critical for cellular proliferation. A growing body of evidence suggests that Plk1 overexpression is tightly associated with the development of human cancers. Interestingly, various types of cancer cells are shown to be addicted to a high level of Plk1, and the reversal of Plk1 addiction appears to be an ...
متن کاملMolecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1.
Polo-like kinases and kinesin-like motor proteins are among the many proteins implicated in the execution of cytokinesis. Polo-like-kinase 1 (Plk1) interacts with the mitotic kinesin-like motor protein CHO1/MKLP-1 during anaphase and telophase, and CHO1/MKLP-1 is a Plk1 substrate in vitro. Here, we explore the molecular interactions of these two key contributors to mitosis and cytokinesis. Usin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Division
سال: 2009
ISSN: 1747-1028
DOI: 10.1186/1747-1028-4-4